KARACHI: In order to create awareness among the healthcare professionals
and promote the use of Low Dose Aspirin therapy in various well
established indications, An Aspirin Update session was organized by
Pakistan Aspirin Foundation during KIHD symposium on Saturday morning
February 10th 2023. It was chaired by Prof. Abdus Samad while the
members of the panel of experts included Prof.M.Ishaq, Prof. Mansoor
Ahmad, Prof.Feroz Memon, Prof. Rashid Khan, Prof.Abid Amin and Prof.
Javed Akbar Seyal. Prof. Fawad Farooq from NICVD and Dr.
Saira Aziz Siddiqui, assistant professor of obstetrics &
Gynaecology at DUHS were the two guest speakers.
Dr. Saira Aziz spoke on use of low dose Aspirin therapy in pregnancy.
She pointed out that Aspirin was being used as prophylaxis in pregnancy,
in patients with still birth, fetal growth restrictions, pre term
births, frequent pregnancy loss as well. Women at high risk of
developing pre eclampsia are also put on low dose aspirin therapy on
regular basis. It must be stated before 12th week of pregnancy. Women
suffering from Type-2 diabetes have high risk of developing other risk
factors. Adverse pregnancy outcome is not a modifiable risk factor. One
should continue aspirin till the 36th week of pregnancy. Start with
150mg for first few weeks and then continue with 75-81mg till the 36th
week of pregnancy some studies have used 100mg dose as well. She laid
emphasis that women must adhere to Aspirin therapy and then also
highlighted some of the reasons for non-adherence which included
forgetting to take it or the pill burden as they also have to take some
Members of the Panel of Experts during the session siting on
the Dais shows from (L to R)
Prof. Abdus Samad, Prof. Ishaq , Prof. Mansoor Ahmed, Prof. Feroz Memon,
Prof. Nawaz Lashari and Prof. Rashid Khan.
In case of pre- term labour the Aspirin trial used 75mg dose, it was
started from sixth to thirteen week of pregnancy which significantly
reduced the pre-term delivery. Aspirin has also been found quite useful
in various gynecological malignancies and it did increase survival.
Aspirin is also being routinely used in sub-fertility cases, she
Prof. Fawad Farooq in his presentation discussed in detail the rational
use of antiplatelet therapy, assessment of cardiovascular diseases and
bleeding risk and shared the present evidence available. CVD, he said is
a progressive disease. Plaque rupture creates problems. He referred to
the adhesions of platelets, their activation and then aggregation in the
arteries. There is a long list of well-established indications for the
use of low dose aspirin therapy, including primary and secondary
prevention. Aspirin, he further stated, cannot prevent IHD but it can
reduce the athero thrombotic events. While prescribing Aspirin one
should always weight the risks and benefits. It is important that all
high risk patients are put on low dose aspirin therapy if there is no
contra indication. He also referred to various trials and shared their
results. He was of the view that it is important that we look at the age
of the patient. In case the patients are between 40-59 years of age,
always discuss with the patient.
Pakistan Aspirin Foundation organized a Session on Aspirin Update during
the Dr.Abdul Haq
Cardiology Symposium organized by Karachi Institute of Heart Diseases.
taken on the occasion shows the members of Panel of Experts alongwith
of the senior
cardiologists and physicians present on this occasion.
Almost all the panelists also favoured the use of low dose aspirin
therapy in high risk patients. Bleeding risk should also be considered
as first it is important to do no harm. Prof. Ishaq and Prof. Mansoor
Ahmad remarked that people are using Aspirin for the last twenty five
years or more but there are no reported side effects or bleeding risks.
As a precautionary measure, one can add PPIs with aspirin therapy. It is
an extremely safe antiplatelet agent which reduces morbidity and
mortality in various disorders significantly.
In his concluding remarks Prof Abdus Samad said that the cardiovascular
disease burden has increased. There is an enormous increase in the
number of primary angioplasties being performed in the country. Patients
survive, some develop heart failure and some complain of stable,
unstable angina. We need to concentrate on prevention of diseases, Hence
it is essential that we act before the event takes place. It is only
possible if we promote the use of low dose aspirin therapy in primary
prevention. There has been an increase in patients suffering from sudden
cardiac death, hence preventive measures should get preference which is
also beneficial and cost effective, he remarked.
Dr. Saira Aziz
Earlier Mr.Shaukat Ali Jawaid General Secretary Paksitan Aspirin
Foundation welcomed the speakers, panelists and participants to the
meeting. He also thanked M/s Atco Laboratories for continuously
sponsoring the CME activities and such academic events for the last many
years despite the fact that keeping up professional ethics, we do not
promote any particular company and a brand name. Mr. Akhtar Director
Marketing and Sales from Atco also briefly addressed the meeting and
thanked all the speakers, members of the Expects Panel and KIHD
administration for providing them an opportunity to organize this